methylsulfonylmethane (MSM) – 1500 mg
glucosamine sulfate – 1500 mg
collagen (type 2) – 600 mg
calcium (as calcium carbonate and calcium ascorbate) – 250 mg
vitamin C (as calcium L-ascorbate) – 90 mg
vitamin D3 – 600 IU
Pharmaceutical formPowder for solution preparation 7,5 g in a sachet.
Properties of components
Glucosamine sulfate is a building material for cartilage tissue, stimulates the production of its own collagen; replenishes endogenous glucosamine deficiency; stimulates the synthesis of proteoglycans and hyaluronic acid in the synovial fluid; increases the permeability of a joint capsule; participates in enzymatic processes in the cells of the synovial membrane and articular cartilage; contributes to the fixation of sulfur during the synthesis of chondroitin sulphuric acid, facilitates the normal deposition of calcium in the bone tissue, helps reduce degenerative processes and painfulness in the joints, and improves their function.
Methylsulfonylmethane (MSM) replenishes the balance of sulfur in the body. Sulfur is involved in the formation of proteins of the most body’s tissues, including chondroitin and glucosamine – the components of cartilage tissue which provide mobility and painless movement. Due to a decrease in the production of pro-inflammatory cytokines, it reduces pain intensity, stiffness and joint swelling, and helps restore the cartilage. MSM reduces muscle pain due to the delivery of sulfur to the connective tissue. The balance of sulfur normalizes the natural production of elastin, keratin and collagen in the body that contributes to strengthening nails and hair. Sulfur is called as a "beauty mineral" since it makes hair shiny and smooth and also improves complexion. The use of MSM reduces the appearance of acne, including rosacea. Due to its ability to protect against the harmful effects of radiation and environmental pollution, sulfur slows down the aging process and generally contributes to the rejuvenation of the body.
Collagen is a protein structure underlying the connective tissue of the body. It is a part of bones, cartilages, tendons, skin, nails and provides their strength and elasticity.
Calcium L-ascorbate is a source of calcium, a well-absorbed form of vitamin C and calcium, easily tolerated, does not irritate the gastric mucosa. Calcium ascorbate is a compound with antioxidant properties, strengthens the immune system and helps strengthen bones and tooth enamel.
Calcium carbonate is a calcium salt with a maximum content of elemental calcium (40%). Calcium is the main structural component of bones and teeth: participates in the formation of bone tissue, helps maintain the mineral density of bone tissue, participates in the mineralization of teeth. There is a decrease in bone tissue density and an increase in the risk of fractures associated with calcium deficiency in adults and children. Calcium is a structural element of nails and hair and has an effect on their condition, strength and appearance.
The normal level of total calcium is 2,2-2,6 mmol/L. The normal level of unbound (ionized) calcium is 1,1-1,4 mmol/L. The biological effect of calcium is determined by the amount of unbound calcium, therefore, hypocalcemia is diagnosed when the levels of unbound calcium decrease. Calcium deficiency can be associated with impaired parathyroid function, vitamin D insufficiency in a diet, the absence of ultraviolet radiation, or impaired renal function. Low levels of vitamin D in the body can lead to decreased calcium absorption.
Cholecalciferol (vitamin D) regulates calcium and phosphorus metabolism, participates in the formation and mineralization of bone tissue, contributes to the absorption of calcium, strengthens muscles and bones, slows down aging, strengthens the immune system.
The use of calcium and vitamin D3 prevents an increase in the production of parathyroid hormone which stimulates the leaching of calcium from the bones.
Multizan Active Bone is recommended for:
slowing down age-related changes and restoring the structure of connective tissue in the joints, cartilages, bone tissue, skin;
improving joint mobility and flexibility;
reducing the dose of NSAIDs and pain medications;
stimulating the production of the body’s own hyaluronic acid;
strengthening bone tissue;
improving life quality in case of osteoarticular pathology.
Route of administration
For adults: dissolve the content of one sachet in 100-150 ml of water at room temperature, take once per day.